Evaluation of Analgesic and Anti-Inflammatory Properties of Combretum racemosum and Combretum platypterum Leaf (Combretaceae) on Rodents

Authors: *Uwaya, D.O., Idu, M. And Ozolua, R.I.

DOI Info: http://doi.org/10.5281/zenodo.21046598

ABSTRACT

Members of the Combretaceae family are Combretum racemosum and Combretum platypterum. Traditional uses of Combretum racemosum include the treatment of roundworm in children, hemorrhoids, haematuria, convulsive coughing, tuberculosis, and circumcision wounds, as well as genito-urinary and gastrointestinal infections that are accompanied by bleeding. In contrast, Combretum platypterum is used to treat fever, malaria, backache, eye issues, swellings, mumps, conjunctivitis, diarrhea, sexually transmitted diseases, and cough. Aqueous leaf extracts from Combretum racemosum and Combretum platypterum were tested in this investigation to see if they had analgesic and anti-inflammatory properties. A hot plate and an acetic acid-induced writhing animal model were used to assess the analgesic property. To test the anti-inflammatory property, carrageenan paw edema in rats was utilized. At doses of 100, 200, and 400 mg/kg, the administration of Combretum racemosum aqueous leaf extract significantly (p<0.01) inhibits pain brought on by acetic acid, as well as significantly (p<0.001) inhibits inflammation brought on by carrageenan. When compared to controls, Combretum platypterum (100, 200, and 400 mg/kg) and aspirin (100 mg/kg) significantly decreased pain in mice induced by acetic acid (P<0.05). It is also noteworthy (p<0.0001, p<0.001, p<0.05) that carrageenan-induced inflammation was inhibited by Combretum platypterum and indomethacin. At any dose level (P > 0.05), neither plant has any influence on the hot plate model when compared to the control. In conclusion, the aqueous leaf extract of Combretum racemosum and Combretum platypterum exhibits analgesic and anti-inflammatory properties.

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